Findings published June 8, 2016 in JNCI: Journal of the National Cancer Institute indicate that high consumption of sweetened beverages may increase the risk of biliary tract cancers (BTCs), particularly gallbladder cancer.
In the study entitled “Sweetened Beverage Consumption and Risk of Biliary Tract and Gallbladder Cancer in a Prospective Study”, Susanna C. Larsson, PhD, and colleagues evaluated the link between sugar-sweetened beverages and the development of BTCs, which have been associated with weight gain and type 2 diabetes.
In a study population of over 70,000 healthy Swedish adults free of cancer and diabetes, 127 incident BTC case patients were ascertained through the Swedish Cancer Register. After adjusting for other risk factors, both men and women with the highest consumption of sweetened beverages were determined to have a statistically significant increased risk of extrahepatic BTC and gallbladder cancer.
- During a mean follow-up of 13.4 years, 127 extrahepatic BTC case patients (including 71 gallbladder cancers) and 21 intrahepati BTC case patients were ascertained.
- The multivariable hazard ratios for two or more servings per day (200mL/serving) of sweetened beverages compared with no consumption were 1.79 (95% confidence interval [CI]
- That same hazard ratio jumped to 2.24 (95% [CI] = 1.02 to 4.89) for gallbladder cancer.
- The corresponding hazard ratio for intrahepatic BTC was 1.69 (95% [CI] = 0.41 to 7.03).
A major strength of this study’s findings is its near complete and objective ascertainment of BTC case patients through its association with the Swedish Cancer Register. The study’s findings support the hypothesis that high consumption of sweetened b